Structure–activity relationship investigation of coumarin–chalcone hybrids with diverse side-chains as acetylcholinesterase and butyrylcholinesterase inhibitors
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چکیده
منابع مشابه
Some new carbacylamidophosphates as inhibitors of acetylcholinesterase and butyrylcholinesterase.
The differences in the inhibition activity of organophosphorus agents are a manifestation of different molecular properties of the inhibitors involved in the interaction with the active site of enzyme. We were interested in comparing the inhibition potency of four known synthesized carbacylamidophosphates with the general formula RC(O)NHP(O)Cl2, constituting organophosphorus compounds, where R ...
متن کاملInhibitors of Acetylcholinesterase and Butyrylcholinesterase Meet Immunity
Acetylcholinesterase (AChE) inhibitors are widely used for the symptomatic treatment of Alzheimer's disease and other dementias. More recent use is for myasthenia gravis. Many of these inhibitors interact with the second known cholinesterase, butyrylcholinesterase (BChE). Further, evidence shows that acetylcholine plays a role in suppression of cytokine release through a "cholinergic anti-infla...
متن کاملthe investigation of the relationship between type a and type b personalities and quality of translation
چکیده ندارد.
Synthesis and biological evaluation of lycorine derivatives as dual inhibitors of human acetylcholinesterase and butyrylcholinesterase
UNLABELLED BACKGROUND Alzheimer's disease (AD) is a neurologically degenerative disorder that affects more than 20 million people worldwide. The selective butyrylcholinesterase (BChE) inhibitors and bivalent cholinesterase (ChE) inhibitors represent new treatments for AD. FINDINGS A series of lycorine derivatives (1-10) were synthesized and evaluated for anti-cholinesterase activity. Resul...
متن کاملAcetylcholinesterase and butyrylcholinesterase as markers of low-grade systemic inflammation.
Low-grade systemic inflammation plays a significant role in the pathogenesis of insulin resistance, type 2 diabetes mellitus, hypertension, hyperlipidemias, Alzheimer’s disease, proliferative diabetic retinopathy; age-related macular degeneration, minimal change nephropathy and various rheumatological conditions.1,2 Hence, development of reliable, unique and robust markers is essential. In this...
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ژورنال
عنوان ژورنال: Molecular Diversity
سال: 2018
ISSN: 1381-1991,1573-501X
DOI: 10.1007/s11030-018-9839-y